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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis interests involve:

It absolutely was only within the nineteen nineties although, when nanotechnology experienced advanced into a amount in which one molecules might be manipulated, that the 1st experimental devices started to look.

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Deposition and atomic power microscopy of personal phthalocyanine polymers among nanofabricated electrodes

This yielded a breakthrough. Inside only some months, we ended up capable to evaluate transport via an individual solitary-walled carbon nanotube. According to very low-temperature experiments by a brilliant PhD scholar in my group, Sander Tans (now a valued colleague and professor at Delft University of Technology using an active investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with quite long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.

The coiled-coil in the human Rad50 DNA repair protein has particular segments of amplified overall flexibility

Numerous associated developments followed, exactly where our group set up distinct transistor variants including solitary-electron transistors at space temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled many transistors into smaller evidence-of-theory electronic circuits.

Stream-pushed rotary motors for example windmills and drinking water wheels generate ceesdekker functional procedures in human Modern society. Although samples of these rotary motors also element prominently in mobile biology, their synthetic construction within the nanoscale has remained complicated. Below we exhibit circulation-driven rotary movement of the self-organized DNA nanostructure that is docked on to a nanopore in a skinny sound-state membrane. An elastic DNA bundle self-assembles right into a chiral conformation upon phoretic docking onto the good-condition nanopore, and subsequently displays a sustained unidirectional rotary movement of up to 20 rev s−1.

Knowing basic procedures regulating the spatial and dynamic organisation with the DNA in Dwell cells.

Resolving the stage size in condensin-pushed DNA loop extrusion identifies ATP binding as being the phase-producing process

Screening pseudotopological and nontopological versions for SMC-driven DNA loop extrusion towards roadblock-traversal experiments

Nanoscientist Cees Dekker is definitely an amiable and flamboyant male who seems much more youthful in comparison to the sixty two many years he in fact is – modern Eyeglasses, psychedelic shirt, engaging smile – but not a single to squander time. He usually takes his time, but not more than essential.

Developments in nanotechnology from the nineties made setting up electronic gadgets from single molecules a possibility. Cees Dekker recounts how his team established a place-temperature transistor based upon only one carbon nanotube.

The biophysicist from Delft – who has been Among the most cited scientists during the Netherlands For a long time – takes his accountability to contribute to your explanation and popularisation of his get the job done in the border of physics and biology exceptionally critically and consistently appears from the media; if not to mention his work, then about the relationship concerning science and his Christian faith.